PUBLICATIONS

# Co-corresponding authors

* Equal contribution

2025

Fridman CM, Keppel K, Rudenko V, Altuna-Alvarez J, Albesa-Jove D, Bosis E#, & Salomon D# (2025) A new class of type 6 secretion system effectors can carry two toxic domains and are recognized through the WHIX motif for export. PLOS Biology, 23(3):e3003053

Kanarek K, Keppel K, Cohen H, Fridman CM, Gerlic M, & Salomon D (2025) Assessing toxicity and competitive fitness of Vibrio isolates from coastal waters in Israel. mSphere, e00025-25

Sachar K, Kanarek K, Colautti J, Kim Y, Bosis E, Prehna G, Salomon D, & Whitney JC (2025) A conserved chaperone protein is required for the formation of a non-canonical type VI secretion system spike tip complex. Journal of Biological Chemistry, 301(3):108242

Lydick NV, Mass S, Pepin R, Podicheti R, Klempic E, Rusch D, Ushijima B, Brown LC, Salomon D, & van Kessel, JC (2024) Quorum sensing regulates virulence factors in the coral pathogen Vibrio coralliilyticus. Applied and Environmental Microbiology, e01143-24

2024

Mahata T, Kanarek K, Goren MG, Ragavan RM, Bosis E#, Qimron U#, & Salomon D# (2024) Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Nature Microbiology, 9(12):3268-3283

Mass S, Cohen H, Gerlic M, Ushijima B, van Kessel JC, Bosis E, & Salomon D (2024) The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence. PLOS Biology, 22(9):e3002734

Schiffmann S, Mass S, & Salomon D (2024) Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus. Microbiology Spectrum, e01181-24

Carobbi A, Di Nepi S, Bosis E, Salomon D#, Sessa, G. (2024) PIX is an N-terminal delivery domain that defines a new class of polymorphic T6SS effectors in Enterobacterales. Cell Reports, 43(4):114015

2023

Mahata, T., Molshanski-Mor, S., Goren, M., Kohen-Manor, M., Yosef, I., Avram, O., Salomon, D., & Qimron, Q. (2023) Inhibition of Host Cell Division by T5 protein 008 (Hdi). Microbiology Spectrum, 11(6):e0169723

Kanarek K, Fridman CM, Bosis E #, & Salomon D# (2023) The RIX domain defines a new class of polymorphic T6SS effectors and secreted adaptors. Nature Communications, 14:4983

Cohen H, Fridman CM, Gerlic M#, & Salomon D# (2023) A Vibrio T6SS-mediated lethality in an aquatic animal model. Microbiology Spectrum, 11(4):e1019323

Tchelet D, Keppel K, Bosis E, & Salomon D (2023) Vibrio parahaemolyticus T6SS2 effector repertoires. Gut Microbes, 15(1): 2178795

2022

Jana B, Keppel K, Fridman CM, Bosis E #, & Salomon D# (2022) Multiple T6SSs, mobile auxiliary modules, and effectors revealed in a systematic analysis of the Vibrio parahaemolyticus pan-genome. mSystems, doi: 10.1128/msystems.00723-22

Fridman CM*, Jana B*, Ben-Yaakov R, Bosis E, Salomon D (2022) A DNase T6SS effector requires its MIX domain for secretion. Microbiology Spectrum, e02465-22

Cohen H, Baram N, Fridman CM, Edry-Botzer L, Salomon D #, & Gerlic M # (2022) Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors. eLife, doi: 10.7554/eLife.82766

Carobbi A*, Di Nepi S*, Fridman CM, Dar Y, Ben-Yaakov R, Barash I, Salomon D #, Sessa, G #. (2022) An antibacterial T6SS in Pantoea agglomerans pv. betae delivers a lysozyme-like effector to antagonize competitors. Environmental Microbiology, 1-16

Tchelet D, Salomon D. (2022) A rapid fluorescence-based screen to identify regulators and components of interbacterial competition mechanisms in bacteria. Methods in Molecular Biology, 2427:11-24

2021

Dar Y *, Jana B *, Bosis E #, Salomon D # (2021) A binary effector module secreted by a type VI secretion system. EMBO Reports, e53981

Jana B, Keppel K, Salomon D (2021) Engineering a customizable antibacterial T6SS-based platfrom in Vibrio natriegens . EMBO Reports , e53681

Popular media coverage:

Times of Israel

ScienMag

שלושה שיודעים (רדיו - דקה 17:20)

Lopez J, Nguyan-Hung L, Moon KH, Salomon D, Bosis E, Feldman M (2021) Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins. J. Bacteriology , doi: 10.1128/JB.00281-21.

Mahata T, Molshanski-Mor S, Goren MG, Jana B, Kohen-Manor M, Yosef I, Avram O, Pupko T, Salomon D #, Qimron U #. (2021) A phage mechanism for selective nicking of dUMP-containing DNA. PNAS USA, 118(23):e2026354118

Popular media coverage:

DoctorsOnly.co.il (Hebew)

2020

Salomon D #, Feldman MF #. (2020) The future of conferences, today: Are virtual conferences a viable supplement to "live" conferences?. EMBO Reports, e50883

Jana B, Salomon D #, Bosis E #. (2020) A novel class of polymorphic toxins in Bacteroidetes. Life Science Alliance, 3(4),doi: 10.26508/lsa.201900631

Fridman CM, Keppel K, Gerlic M, Bosis E #, Salomon D #. (2020) A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors. Nature Communications, 11:1085

Read accompanying 'Behind The Paper' blog post on Nature Research Microbiology Community: "Shall I compare thee to another strain?"

Cohen H*, Baram N*, Edry-Botzer L, Salomon D #, Gerlic M #. (2020) Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome. Emerging Microbes & Infections, 9(1):278-290

2019

Jana B, Salomon D. (2019) Type VI secretion system: a modular toolkit for bacterial dominance. Future Microbiology, doi:10.2217/fmb-2019-0194.

Jana B*, Fridman CM*, Bosis E #, Salomon D #. (2019) A modular effector with a DNase domain and a marker for T6SS substrates. Nature Communications, 10:3595.

Read accompanying 'Behind The Paper' blog post on Nature Research Microbiology Community: "Bactender, FIX me a killer cocktail"

Additional comments on this publication in popular media can be found in our "News" section

Ben-Yaakov R, Salomon D. (2019) The regulatory network of Vibrio parahaemolyticus type VI secretion system 1. Environmental Microbiology, 21(7). 2248-2260.

2018

Dar Y, Salomon D #, Bosis E #. (2018) The antibacterial and anti-eukaryotic type VI secretion system MIX-effector repertoire in Vibrionaceae. Marine Drugs, 16, 433.

2017

Ray A, Schwartz N, de Souza Santos M, Zhang J, Orth K, Salomon D. (2017) Type VI secretion system MIX-effectors carry both anti-bacterial and anti-eukaryotic activities. EMBO Reports, 10.15252/embr.201744226.

Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunen LM, Camilli A, Grishin NV, Salomon D #, Orth K #. (2017) Acute Hepatopancreatic Necrosis Disease (AHPND)- causing Vibrio parahaemolyticus strains maintain an antibacterial Type VI Secretion system with versatile effector repertoires. Appl Environ Microbiol., 83(13):e00737-17.

de Souza Santos M, Salomon D, Orth K. (2017) T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus. PLoS Pathogens, 13(6):e1006438.

2016

Ray A, Kinch LN, de Souza Santos M, Grishin NV, Orth K #, Salomon D #. (2016) Proteomics analysis reveals previously uncharacterized virulence factors in Vibrio proteolyticus. mBio. 7(4):e01077-16.

Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick D, Grishin NV, Orth K. (2016) Bile salt receptor complex activates a pathogenic type III secretion system. eLife, 10.7554/eLife.15718.

Salomon D. (2016) MIX and match: mobile T6SS MIX-effectors enhance bacterial fitness. Mob Genet Elements, 13;6(1):e1123796.

Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G. (2016) Identification of novel Xanthomonas euvesicatoria type III effector proteins by a machine-learning approach. Mol Plant Pathol., 17(3):398-411.

2015

Salomon D #, Klimko JA, Trudgian DC, Kinch LN, Grishin NV, Mirzaei H, Orth K # . (2015) Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria. PLoS Pathog., 25;11(8):e1005128.

De Souza Santos M, Salomon D. Li P, Krachler AM, & Orth K. (2015) Vibrio parahaemolyticus virulence determinants. The Comprehensive Sourcebook of Bacterial Protein Toxins, 4th addition, Acad. Press, ed., pp 230-260.

Salomon D #, Orth K. (2015) Type VI secretion system. Curr Biol., 30;25(7):R265-6.

2014

Calder T, de Souza Santos M, Attah V, Klimko J, Fernandez J, Salomon D, Krachler AM, Orth K. (2014) Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence. FEMS Microbiol Lett., 361(2):107-14.

Salomon D, Klimko JA, Orth K. (2014) H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1. Microbiology, 160(Pt 9):1867-73.

Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K. (2014) Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins. PLoS One, 6;9(8):e104387.

Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H, Orth K. (2014) Marker for type VI secretion system effectors. Proc Natl Acad Sci U S A., 24;111(25):9271-6.

Teper D, Salomon D, Sunitha S, Kim JG, Mudgett MB, Sessa G. (2014) Xanthomonas euvesicatoria type III effector XopQ interacts with tomato and pepper 14-3- 3 isoforms to suppress effector-triggered immunity. Plant J., 77(2):297-309.

2013

Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. (2013) Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Commun., 4:2973.

Salomon D, Orth K. (2013) What pathogens have taught us about posttranslational modifications. Cell Host Microbe. 11;14(3):269-79.

Sreeramulu S, Mostizky Y, Sunitha S, Shani E, Nahum H, Salomon D, Hayun LB, Gruetter C, Rauh D, Ori N, Sessa G. (2013) BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis. Plant J., 74(6):905-19.

Salomon D, Gonzalez H, Updegraff BL, Orth K. (2013) Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2. PLoS One., 16;8(4):e61086.

Salomon D, Orth K. (2103) Lost after translation: post-translational modifications by bacterial type III effectors. Curr Opin Microbiol., 16(2):213-20.

2012 and earlier

Salomon D *, Bosis E *, Dar D, Nachman I, Sessa G. (2012) Expression of Pseudomonas syringae type III effectors in yeast under stress conditions reveals that HopX1 attenuates activation of the high osmolarity glycerol MAP kinase pathway. Microbiology,158(Pt 11):2859-69.

Salomon D, Dar D, Sreeramulu S, Sessa G. (2011) Expression of Xanthomonas campestris pv. vesicatoria type III effectors in yeast affects cell growth and viability. Mol Plant Microbe Interact., 24(3):305-14.

Bosis E *, Salomon D *, Sessa G. (2011) A simple yeast-based strategy to identify host cellular processes targeted by bacterial effector proteins. PLoS One., 6(11):e27698.

Salomon D, Zhang C, Shokat KM, Sessa G. (2011) Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods Mol Biol., 779:185-97.

Salomon D, Sessa G. (2010) Identification of growth inhibition phenotypes induced by expression of bacterial type III effectors in yeast. J Vis Exp., 30;(37). pii: 1865.

Bosis E *, Salomon D *, Ohayon O * , Sivan G, Bar-Nun S, Rabinovich E. (2010) Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1- npl4 complex by upregulating cdc48. Genetics, 184(3):695-706.

Salomon D, Bonshtien A, Sessa G. (2009) A chemical-genetic approach for functional analysis of plant protein kinases. Plant Signal Behav., 4(7):645-7.

Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G. (2009) Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. J Biol Chem., 29;284(22):15289-98.

Publications